Seleziona una pagina

Colesterolo sì, statine no. Perché?

Nov 27, 2023 | Alimentazione, Infiammazione, Medicina Preventiva

Decenni di linee guida ci suggeriscono di abbattere i nostri livelli di colesterolo e di non mangiare grassi. Ma davvero è così? E se il nostro vero rischio cardiovascolare dipendesse da altro e da fattori più specifici?

In questo nuovo “LONG” ti racconto quali sono davvero le cose a cui fare attenzione, ti racconto perché il colesterolo è “il padre di tutti gli dei” e perché l’assunzione di statine può dare problemi.

Questo video è per abbonati al mio canale YouTube. Qui il link esatto.

Le informazioni in questo video non vanno intese come consigli medici ma come semplice divulgazione. Ogni situazione clinica va valutata da un medico, per cui prima di prendere qualsiasi decisione riguardante la tua salute fatti aiutare da un professionista.

Iscriviti alla newsletter!

* indicates required

Bibliografia

  • Pennisi M, Di Bartolo G, Malaguarnera G, Bella R, Lanza G, Malaguarnera M. Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain. Dis Markers. 2019 Mar 25;2019:3549402. doi: 10.1155/2019/3549402. PMID: 31019583; PMCID: PMC6452565.
  • Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Bhatt DL. Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy. Circulation. 2022 Aug 2;146(5):372-379. doi: 10.1161/CIRCULATIONAHA.122.059410. Epub 2022 Jun 28. PMID: 35762321.
  • Staprans I, Pan XM, Rapp JH, Feingold KR. The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis. Mol Nutr Food Res. 2005 Nov;49(11):1075-82. doi: 10.1002/mnfr.200500063. PMID: 16270280.
  • Heitzer T, Schlinzig T, Krohn K, Meinertz T, Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001 Nov 27;104(22):2673-8. doi: 10.1161/hc4601.099485. Erratum in: Circulation. 2003 Jul 29;108(4):500. PMID: 11723017.
  • Choi SH, Sviridov D, Miller YI. Oxidized cholesteryl esters and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Apr;1862(4):393-397. doi: 10.1016/j.bbalip.2016.06.020. Epub 2016 Jun 29. PMID: 27368140; PMCID: PMC5199681.
  • Robbie L, Libby P. Inflammation and atherothrombosis. Ann N Y Acad Sci. 2001 Dec;947:167-79; discussion 179-80. doi: 10.1111/j.1749-6632.2001.tb03939.x. PMID: 11795264.
  • Vainshelboim B, Myers J. Dyslipidemia paradox: Analysis from the veterans exercise testing study. PLoS One. 2023 Jul 19;18(7):e0287923. doi: 10.1371/journal.pone.0287923. PMID: 37467298; PMCID: PMC10355403.
  • Dabhi KN, Gohil NV, Tanveer N, Hussein S, Pingili S, Makkena VK, Jaramillo AP, Awosusi BL, Ayyub J, Nath TS. Assessing the Link Between Statins and Insulin Intolerance: A Systematic Review. Cureus. 2023 Jul 17;15(7):e42029. doi: 10.7759/cureus.42029. PMID: 37465091; PMCID: PMC10351747.
  • Parthasarathy S, Raghavamenon A, Garelnabi MO, Santanam N. Oxidized low-density lipoprotein. Methods Mol Biol. 2010;610:403-17. doi: 10.1007/978-1-60327-029-8_24. PMID: 20013192; PMCID: PMC3315351.
  • Rist PM, Buring JE, Ridker PM, Kase CS, Kurth T, Rexrode KM. Lipid levels and the risk of hemorrhagic stroke among women. Neurology. 2019 May 7;92(19):e2286-e2294. doi: 10.1212/WNL.0000000000007454. Epub 2019 Apr 10. PMID: 30971484; PMCID: PMC6537127.
  • Ma C, Gurol ME, Huang Z, Lichtenstein AH, Wang X, Wang Y, Neumann S, Wu S, Gao X. Low-density lipoprotein cholesterol and risk of intracerebral hemorrhage: A prospective study. Neurology. 2019 Jul 30;93(5):e445-e457. doi: 10.1212/WNL.0000000000007853. Epub 2019 Jul 2. PMID: 31266905; PMCID: PMC6693427.
  • Grunwald SA, Haafke S, Grieben U, Kassner U, Steinhagen-Thiessen E, Spuler S. Statins Aggravate the Risk of Insulin Resistance in Human Muscle. Int J Mol Sci. 2022 Feb 21;23(4):2398. doi: 10.3390/ijms23042398. PMID: 35216514; PMCID: PMC8876152.
  • Abbasi F, Lamendola C, Harris CS, Harris V, Tsai MS, Tripathi P, Abbas F, Reaven GM, Reaven PD, Snyder MP, Kim SH, Knowles JW. Statins Are Associated With Increased Insulin Resistance and Secretion. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2786-2797. doi: 10.1161/ATVBAHA.121.316159. Epub 2021 Aug 26. PMID: 34433298; PMCID: PMC8551023.
  • Ohgami N, Miyazaki A, Sakai M, Kuniyasu A, Nakayama H, Horiuchi S. Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism. J Atheroscler Thromb. 2003;10(1):1-6. doi: 10.5551/jat.10.1. PMID: 12621157.
  • McCully KS. Chemical Pathology of Homocysteine VII. Cholesterol, Thioretinaco Ozonide, Mitochondrial Dysfunction, and Prevention of Mortality. Ann Clin Lab Sci. 2019 Sep;49(4):425-438. PMID: 31471331.
  • Paul R, Dutta A, Phukan BC, Mazumder MK, Justin-Thenmozhi A, Manivasagam T, Bhattacharya P, Borah A. Accumulation of Cholesterol and Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice. Neuroscience. 2018 Sep 15;388:347-356. doi: 10.1016/j.neuroscience.2018.07.041. Epub 2018 Aug 1. PMID: 30075243.
  • Feig JE, Feig JL, Dangas GD. The role of HDL in plaque stabilization and regression: basic mechanisms and clinical implications. Coron Artery Dis. 2016 Nov;27(7):592-603. doi: 10.1097/MCA.0000000000000408. PMID: 27414247; PMCID: PMC5042826.
  • Ivanova EA, Myasoedova VA, Melnichenko AA, Grechko AV, Orekhov AN. Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases. Oxid Med Cell Longev. 2017;2017:1273042. doi: 10.1155/2017/1273042. Epub 2017 May 7. PMID: 28572872; PMCID: PMC5441126.
  • Fernandez ML, Murillo AG. Is There a Correlation between Dietary and Blood Cholesterol? Evidence from Epidemiological Data and Clinical Interventions. Nutrients. 2022 May 23;14(10):2168. doi: 10.3390/nu14102168. PMID: 35631308; PMCID: PMC9143438.
  • Gershuni VM. Saturated Fat: Part of a Healthy Diet. Curr Nutr Rep. 2018 Sep;7(3):85-96. doi: 10.1007/s13668-018-0238-x. PMID: 30084105.
  • Sabolová M, Pohořelá B, Fišnar J, Kouřimská L, Chrpová D, Pánek J. Formation of oxysterols during thermal processing and frozen storage of cooked minced meat. J Sci Food Agric. 2017 Dec;97(15):5092-5099. doi: 10.1002/jsfa.8386. Epub 2017 May 30. PMID: 28418171.
  • Cenik B, et al. Plasma sterols and depressive symptom severity in a population-based cohort. PLoS One. 2017;12:e0184382. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184382. Accessed Oct. 29, 2018.
  • The Great Cholesterol Con by Dr Malcolm Kendrick. Pub: John Blake Publishing Ltd, 2007
  • Lipid levels and the risk of hemorrhagic stroke among women Pamela M. Rist, Julie E. Buring, Paul M Ridker, Carlos S. Kase, Tobias Kurth, Kathryn M. Rexrode Neurology May 2019, 92 (19) e2286-e2294; DOI:10.1212/WNL.0000000000007454
  • Gradinaru D, Borsa C, Ionescu C, Prada GI. Oxidized LDL and NO synthesis–Biomarkers of endothelial dysfunction and ageing. Mech Ageing Dev. 2015 Nov;151:101-13. doi: 10.1016/j.mad.2015.03.003. Epub 2015 Mar 21. PMID: 25804383.
  • Farmer BC, Walsh AE, Kluemper JC, Johnson LA. Lipid droplets in neurodegenerative disorders. Front Neurosci. 2020; 14(742).
  • Stanciulescu LA, Scafa-Udriste A, Dorobantu M. Exploring the Association between Low-Density Lipoprotein Subfractions and Major Adverse Cardiovascular Outcomes-A Comprehensive Review. Int J Mol Sci. 2023 Apr 3;24(7):6669. doi: 10.3390/ijms24076669. PMID: 37047642; PMCID: PMC10095470.
  • Blesso CN, Andersen CJ, Barona J, Volek JS, Fernandez ML. Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome. Metabolism. 2013 Mar;62(3):400-10. doi: 10.1016/j.metabol.2012.08.014. Epub 2012 Sep 27. PMID: 23021013.
  • Bostan M, Uydu HA, Yildirmis S, Malkoç M, Atak M, Demir A, Yilmaz A, Uğurlu Y, Karadağ Z, Duman H, Satiroğlu O. Pleiotropic effects of HDL subfractions and HDL-associated enzymes on protection against coronary artery disease. Acta Cardiol. 2015 Jun;70(3):333-40. doi: 10.2143/AC.70.3.3080638. PMID: 26226707.
  • Hansen CD, Gram-Kampmann EM, Hansen JK, Hugger MB, Madsen BS, Jensen JM, Olesen S, Torp N, Rasmussen DN, Kjærgaard M, Johansen S, Lindvig KP, Andersen P, Thorhauge KH, Brønd JC, Hermann P, Beck-Nielsen H, Detlefsen S, Hansen T, Højlund K, Thiele MS, Israelsen M, Krag A. Effect of Calorie-Unrestricted Low-Carbohydrate, High-Fat Diet Versus High-Carbohydrate, Low-Fat Diet on Type 2 Diabetes and Nonalcoholic Fatty Liver Disease : A Randomized Controlled Trial. Ann Intern Med. 2023 Jan;176(1):10-21. doi: 10.7326/M22-1787. Epub 2022 Dec 13. PMID: 36508737.
  • Hargreaves I, Heaton RA, Mantle D. Disorders of Human Coenzyme Q10 Metabolism: An Overview. Int J Mol Sci. 2020 Sep 13;21(18):6695. doi: 10.3390/ijms21186695. PMID: 32933108; PMCID: PMC7555759.
  • Deichmann R, Lavie C, Andrews S. Coenzyme q10 and statin-induced mitochondrial dysfunction. Ochsner J. 2010 Spring;10(1):16-21. PMID: 21603349; PMCID: PMC3096178.
  • Carson JAS, Lichtenstein AH, Anderson CAM, Appel LJ, Kris-Etherton PM, Meyer KA, Petersen K, Polonsky T, Van Horn L; American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Peripheral Vascular Disease; and Stroke Council. Dietary Cholesterol and Cardiovascular Risk: A Science Advisory From the American Heart Association. Circulation. 2020 Jan 21;141(3):e39-e53. doi: 10.1161/CIR.0000000000000743. Epub 2019 Dec 16. PMID: 31838890.
  • Younis N, Sharma R, Soran H, Charlton-Menys V, Elseweidy M, Durrington PN. Glycation as an atherogenic modification of LDL. Curr Opin Lipidol. 2008 Aug;19(4):378-84. doi: 10.1097/MOL.0b013e328306a057. Erratum in: Curr Opin Lipidol. 2008 Oct;19(5):552. PMID: 18607185.

0 commenti

Invia un commento

Il tuo indirizzo email non sarà pubblicato. I campi obbligatori sono contrassegnati *